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This immunomodulatory effect was accompanied by significant anti-catabolic activity, as liraglutide reduced the activity of metalloproteinases and aggrecanases-key enzymes responsible for cartilage degradation [45] (Fig
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24 With respect to linking reward to hedonic experience, recent evidence points to an important role for the orbitofrontal cortex (OFC), an area that receives converging sensory input
